Stricter coronavirus rules are coming into force for nearly six million people in Britain on Friday.
Greater Manchester’s population of 2.8 million joined Liverpool City Region and Lancashire in England’s highest tier of restrictions at midnight.
And at 18:00 BST, the 3.1 million people in Wales will go into a 17-day “firebreak” lockdown.
The UK recorded another 189 deaths and 21,242 new confirmed cases on Thursday.
On Saturday at 00:01, South Yorkshire will also move into tier three restrictions – bringing the total number of people living under England’s tightest rules to more than seven million.
The tier three, “very high” alert level means pubs and bars will be closed – unless they are serving substantial meals – along with casinos, bingo halls, betting shops and soft play centres.
Households are banned from mixing outdoors in private gardens or in hospitality venues and people are advised against travelling into or out of the area.
In addition, rising infections mean that Coventry, Stoke and Slough will move into tier two restrictions at 00:01 on Saturday.
The “high” alert level means that households are banned from mixing indoors, pubs and restaurants must close at 22:00 and people are encouraged to reduce their use of public transport.
Talks between the government and local leaders in Nottingham and Warrington over introducing tier three restrictions are due to take place on Friday. In Wales, the “firebreak” means people are being ordered to stay at home and pubs, restaurants, hotels and non-essential shops will close until 9 November.Supermarkets have been told not to sell items such as clothes, as First Minister Mark Drakeford said it would be “made clear” that they should only open the parts of their business that sell essential goods.And the Scottish government is to set.